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The mechanisms include blood pressure reduction, improvement in lipid profiles, anti-inflammatory effects on the arterial wall, and possible direct cardioprotective effects through GLP-1R expressed on cardiomyocytes

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These three use cases reflect different biological contexts and different expected time horizons for response

IM injections involve the direct administration of vitamin B12 into the muscle tissue, typically in the form of hydroxocobalamin or methylcobalamin

Many patients report decreasing pain and improving function during this phase